A Better Pace

Improving your heart’s efficiency

Our Harmony™ System was designed for heart failure patients and is a minimally invasive neuromodulation implant supplies precise and personalized aortic stimulation, while the wearable unit allows the user to switch the therapy on or off, as needed.

The Harmony System can be implanted in 30 minutes in a standard catheterization procedure, without the need for general anesthesia.

Communicating Antenna

Rechargeable Battery

Aortic Implant

target antenna
target aortic
target battery
What is heart failure?

Heart failure is a condition that develops when your heart is unable to pump enough blood around the body properly. When your heart has less pumping power, there is an increase in pressure in the heart and lungs, fluid may build up in or around your lungs and causing congestion and making it hard to breathe during activities or even when at rest. Heart failure may not cause symptoms right away. But eventually, you may feel tired, short of breath and notice fluid buildup in your lower body, around your stomach, or your neck.
Heart failure means that Your heart just needs some support to help it work better

Heart failure with preserved ejection fraction (HFpEF), also referred to as diastolic heart failure, causes almost one-half of the 5 million cases of heart failure in the United States and continues to increase in the developed world.

HFpEF is a clinical syndrome in which patients have signs and symptoms of Heart failure as the result of high left ventricular (LV) filling pressure despite normal or near normal LV ejection fraction (LVEF; ≥50 percent). It is more common among older patients and women and can be measured by echocardiography or cardiac catheterization.

The first step in the diagnosis of HFpEF is recognition of possible heart failure and subsequent referral for two-dimensional transthoracic echocardiography (TTE) to confirm the diagnosis. The diagnosis of HFpEF requires clinical symptoms and/or signs of heart failure, as well as evidence of preserved LVEF and diastolic dysfunction.

Hypertension hyperlipidemia, older age, female sex, diabetes, smoking, obstructive, sleep apnea, obesity, metabolic syndrome, and sedentary lifestyle have been identified as important risk factors for diverse types of heart disease, including HFpEF.

People who have heart failure may have the following symptoms

The Harmony™ System

Implanted Unit

This "stent-like" unit delivers electrical stimulation to the aorta's inner wall.

Battery-free, the implant contains a miniature, sealed neurostimulator, a receiving RF antenna, and dedicated electrodes.

Wearable Unit

This external unit powers and communicates the the implant during neuromodulation therapy.

It contains a transmitting RF antenna and a control unit that stores the stimulation regime

Physician Unit

This unit enables wireless communication with the implant, to set the stimulation regime, and enables physicians to adjust therapy according to each patient's needs

It contains a miniature stationary unit with a wireless communication antenna.
The Harmony System is limited for investigational use only.

How It Works

Simple Implantation Procedure

Remote Monitoring

Personalized Treatment

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During my acquaintance with the Enopace team, they have been efficient, professional and organized. They have my warm recommendation.

Israel Israely, MD,
Rambam Hospital

We Believe

We believe that life is not just about
living longer but how you live it!

We believe each person and patient is unique.

We believe each person and patient needs a therapeutic product or technology that can be personalized to their condition.

Management Team

David Handler
President and CEO
Yoav Katz
VP R&D
Erez Adunsky
Director of Operations & Manufacturing
David Katz
VP RA & QA
Gracielle
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Board of Directors

David Steinhaus, MD
Executive Chairman
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Ilan Neugarten
Rainbow Medical
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Yossi Gross
Rainbow Medical
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Guy Ezekiel, MD
Pitango HealthTech
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Susan Lin
LivaNova
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Jiawen Shen
China Universal Life Science Investment Capital

Scientific Advisers

Prof. Dan Burkhoff, MD, PhD
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Prof. Andrew Coats, MD
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Contact Us

    *Email


    Enopace Biomedical Ltd.

    5 Tarshish St.
    Business Park, North
    P.O.B 3546 Caesarea 3079821, Israel

    CEO Profile Image

    David Handler

    President and CEO

    David M. Handler joined as President and Chief Executive Officer of Enopace Biomedical in March of 2023. Prior to joining Enopace, Mr. Handler served as Global Vice President and General Manager of Philips Healthcare’s Cardiology Ultrasound Business where he achieved significant annual growth in revenue, market share and profitability. He also led important M & A activities including the acquisition of TOMTEC imaging systems and development, FDA clearance and commercialization of breakthrough AI applications for Echo analysis. Previously, he was President and CEO of Corindus Vascular Robotics where he led the development of the CorPath robotic system, from prototype through IDE clinical trial, FDA clearance and commercialization with more than 100 employees. The CorPath system was the first cath lab robot ever used for coronary stenting procedures. He also drove Corindus’ development from a venture backed private company with five employees to a publicly traded company and IPO raising more than $90m and more than 100 employees. Corindus was eventually acquired by Siemens Healthcare for $1.1B after Mr. Handler had departed.

    Prior to Corindus he held General Manager positions at General Electric from October 1998 until September 2008. Mr. Handler has over 30 years of successful service in sales, product management, marketing and leadership roles in the medical device, medical imaging and informatics and plastics industries. Mr. Handler earned a B.A. in Economics from Union College in Schenectady, New York and completed Executive Leadership and Management Programs at the GE Management Development Institute.

    Yoav Katz

    Yoav Katz

    VP R&D

    Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem

    Contrary to popular belief, Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur

    Erez Adunsky

    Erez Adunsky

    Director of Operations & Manufacturing

    Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem

    Contrary to popular belief, Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur

    David Katz

    David Katz

    VP RA & QA

    Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem

    Contrary to popular belief, Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur

    Gracielle

    Gracielle

    Lorem Ipsum

    Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem

    Contrary to popular belief, Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur

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